It took me hours to figure out how to make a singular tile in Blender, but that’s just because I am very simple. What I did make I am very proud of, though, since it was a whole process of the ground not appearing, then the Start position not placing, and then finally the hit material being incorrect.
But now I have it and I couldn’t be more pleased.
I guess what I’m saying is, if I can do it, you certainly can! Go chase those Blender tileset dreams!!
This looks really good.
Well done!
Thank you! 
The Do it in Blender! tutorials have been indispensable in my efforts. There are a few places where some basic knowledge of Blender is assumed, so that’s been a humbling learning process.
You might be interested in this thread (Single Tile Tileset Help Needed) and also what @Zwerkules made as a response to it -
Hope this of help.
TR
Oh! That was the base I used! 
Yes, it is indeed very helpful! It’s nice to have a basis to start from.